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07.28.2016

Malaria, cancer drug prospects emerge from open-source test

UW Medicine scientist led global project to ID potential disease-fighting compounds

By Bobbi Nodell  |  HSNewsBeat  |  Updated 11:00 AM, 07.28.2016

Posted in: Research

  • Mosquito netting protects a woman and child. Options for malaria prevention and treatment have narrowed as the disease has grown resistant to known compounds. Bill & Melinda Gates Foundation

In what is being called the first-ever test of open-source drug-discovery, researchers from around the world have successfully identified compounds to pursue in treating and preventing parasite-borne illnesses such as malaria as well as cancer.

Starting in late 2011, the Medicines for Malaria Venture, based in Geneva, Switzerland, distributed 400 diverse compounds with antimalarial activity free of charge to 200 labs in 30 countries. One-third of the labs reported their results in a paper published today in PLOS Pathogens, “Open source drug discovery with the Malaria Box compound collection for neglected diseases and beyond.”  

The results have ignited more a dozen drug-development projects for a variety of diseases. 

malaria box
Medicines for Malaria Venture
The box of 400 active drug-like molecules was distributed at no cost to researchers around the world.
picture of the "Malaria Box" of 400 active druglike molecules

“The trial was successful not only in identifying compounds to pursue for anti-malarials, but it also identified compounds to treat other parasites and cancer,“ said lead author Wesley Van Voorhis. To help lead the project, Van Voorhis took a sabbatical from his roles as a University of Washington professor of medicine (allergy and infectious diseases) and director of the Center for Emerging and Re-emerging Infectious Diseases.  

The National Cancer Institute is now working on a colon cancer drug that emerged from the testing, Van Voorhis said. Several European labs are working on anti-worm compounds, and numerous U.S. labs are investigating drugs to combat other parasites. Medicines for Malaria Venture is also working with pharmaceutical companies GSK and Novartis on related anti-malarials, he added.

In their paper, researchers cited the lack of interaction between academia and industry as a major curb to innovation in drug discovery. 

“Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still largely within industry. Open-source drug discovery, with sharing of information, is clearly a first step towards overcoming that gap,” they wrote.  

The Malaria Box distributed 400 diverse druglike molecules that were most often found in industry collections, helping to bridge the gap between industry and academia.

This open-access effort was so successful that Medicines for Malaria Venture has begun to distribute another set of compounds with broader potential applicability, called the Pathogen Box. The box is available now to scientific labs globally. 

Tagged with: malaria, cancer, parasites, drug discovery
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